I suspect you already know its all about application. 377 is generally better for a well geared light race car or a light drag car. For about everything else a 406 is better hands down. RPM = ruins peoples motors. Why spin the snot out of it if you can make the same HP and more torque down (more stroke) in a more useable rpm range and an rpm range that your engine can live a much longer life with. More cubes is more torque which is almost always a good thing. For a (relative) heavy street car the benefits are more and deeper than I want to list.
In the muscle car era if it had a small block it was your moms car.
When you turn your car on does she return the favor? Life's short enjoy your ride. Hybrid burns gas & rubber. Check out my photo album.87 Olds 442,
Blue on Metalic Silver with 275/60/15 drag radials on 15x8 442 wheels, 10-1 509ci Cadillac, 800cfm Q-jet, Performer intake, Street ported heads, 230@50 518 lift cam, Headers, Built 200-4R, 2800 stall lock-up converter, Electric fans & in-tank fuel pump, Factory AC, All factory guages work including tach & oil temp with the 509, Functional Hurst hood & rear spoiler, 36mm hollow sway bar, 3.42 posi 8.5, 17.0 mpg hwy, sold 87 Buick Grand National,
Tuxedo Black w Chrome 275/50 drag radials on 15x8 GN wheels, 231 Buick V6, TE-60 turbo, Stretch intercooler, 42.5lb injectors, 3" downpipe, 3000 stall lock-up converter, Meth/water injection, 3.42 posi 8.5, 22 mpg hwy, original owner ~ Goal for both cars 11.8 ETs / 115 mph in the quarter reliably on pump gas