Physically swapping the radio and A/C control unit wouldn't be hard but you would have to cut out part of the dash for the radio and fabricate mounting plates for both and you would need to do something with the bezel, but the reality is I think since the AC controls were designed for that location they might not have the play with hoses/cables etc. or clearance to go where the radio is.
I am curious as to why or what advantage do you see in doing this?
I was also wondering about the play in the wires and such.
I was looking into doing this to put in a head unit that has a display that comes out of the radio and flips up. I the stock position it would be in front of the A/C controls.
Does this sound crazy?
No, you could remove your radio and then unbolt your AC controls and gently try to move it down to see if it looks like it will work.
You could also do an under dash mount for the new radio and not move anything.