If you are talking about the 87 Cutlass Euro composite lights, then no - not even close.
That is not to say that SOMEbody MAY have tried it in the past, but not without major cutting and fashioning of the header panel i pressume.
You would also have to do a major cut up of the bezels on your regal as it would not fit around the headlight at all.
Weather stripping should be available from multiple sources for the 2 door.
I have found 4 door weatherstripping sitting in dealerships by doing a GMpartsvoice search. Need to know the part number first thou. Never tried looking for 2door weatherstrip on PartsVoice.