Ok here goes nothin, I too have been down the Holley Highway to Hell. Same scenario, Small Block Chevy on the street, Vacuum then mechanical with no improvement and a lot more wasted fuel[mileage and fouled plugs] So I finally invested in a Holley Performance book and Wow did I learn a Bunch ! Specifically I learned that every model carb Holley or Quadrajet have their own idiosyncrasies [ engineered in problems]. It was enlightening to learn and fix my own carb , which by the way lead me to helping many others do the same. I wish I still had this book. Lent it to another Body man I worked with in Tampa and that was the last I saw of it. So if you have the time and want to learn some Good Stuff try buying the latest copy of the Guide to Holley Cards.
Best of Luck to you.