It's possible, but, some of the bolts are a pain to get at and the passenger side is complicated by the antenna. You've also got to remove some brackets and braces, etc. And you may find yourself
Is it possible to remove just the outer fender, and leave the inner fender and wheel well on the car? It would eliminate finding a extra set of hands to remove the hood. It looks like I can if I unbolt the header panel and bumper cover from the outer fender, and move them forward a half inch or so. Wondering if there are any bolts that are hidden until you take the whole assembly off of the car. Need to do some paintless dent repair on my 87 442
If your goal is to eliminate some of the time on alignment... well...
Here's the thing. To get the fender skin off you STILL need to unbolt the hood hinge as it bolts on top of the fender near the windshield/cowl end of things. So you still need to support the hood, and still need to align it after the fact. You can avoid unbolting the spring, but, that doesn't keep everything aligned. The hinge end does that.
Meanwhile, you also need to remove/have issues with braces including the ones that connect to the core support, and, I'm trying to remember if part of the skin wraps over behind the header panel between the inner steel fender and the core support. (Others can chime in on that, I know it does on some gbodies.)
Meanwhile, for your trouble, you get lots of tough to access bolts in the door jamb and elsewhere, and risks of scratching paint, etc.
Plenty of people just pull one fender, but usually its because it needs to get done. It's not much of a shortcut IMO