Who runs 350-400 psi? My high side pressure is 150psi. Low side is 30 to 40. Even R-134a will burn at 5 psi, at only 375*, not to mention the oils used in AC systems are flammable which is why the gasses are tested minus the oil. I can't imagine an explosion potential unless the entire system was released into the passenger compartment via the evaporator suffering a massive rupture and then somehow getting ignited. Since the evaporator is protected inside the heating/AC housing, how might that happen? A collision? I'm thinking a collision that would collapse that part of the firewall would be so bad that the AC leaking out is the least of your problems. Under the same circumstances the R-134a would suffocate you. I think the fire hazard is no worse than the usual fuel or electrical systems we take for granted. In fact I would be more afraid of a rubber fuel hose that was used instead of a steel line or spliced in glass fuel filter leaking and the fan blowing fuel all over the distributor.