If a mild to moderate performance street cam is most efficient (fuel to power) at around 2,200 rpms then that should be your ideal cruise/travel rpm.
Useing Wallace racing automotive calculators;
http://www.wallaceracing.com/calcmph.php
2,200 rpms, 27" tire, 3.73 gear, .67 overdrive = 70.7 mph
2,200 rpms, 27" tire, 3.08 gear, .67 overdrive = 85.6 mph
What speed do you normally cruise/travel at?
Best ET comes around your maximum horsepower rpm in 3rd gear.
How much horsepower do you expect to make and at what rpm?
From that with your cars race weight you can roughly determine your best possible 1/4 mile mph.
Match that with the gear that will put you closest to that rpm at that speed in third gear. You just determined your best 1/4 mile gear.
For example if max horsepower is at 5,000 rpms and your motor can push your car with ideal gearing to 100 mph in the 1/4.
3.73 = 5,000 at 107.7 mph
3.08 = 5000 at 130 mph
Then which gear gets you closest to useing all of your available power? It is also the gear that will give you the better et. In this scenario they are both still conservatively geared.