From my experience, yes, most definately run new lines. I used my old main line as the return, the V6 that came out was running fine as far as I could tell (not that a V6 required a lot of fuel anyway). Long story short, I couldn't get my fuel press below 100 psi. The old main (now return) was plugged and wouldn't let the fuel return back to the tank. I ran a new return back to the tank, pressure returnedback to normal.
Since you really need a 3/8" main for fuel injection and a g-body has only 5/16" lines, running a new main AND return isn't that much more cost or time consuming and may circumvent a problem before it even rears it's ugly head.