My gbody doesnt have that many miles, but We have a couple vehicles with around 190k miles. Keeping the oil & filter changed is the main thing! Keep the fluids topped off & check them regular as well ! As long as you keep the oil changed & check it & all the fluids regularly, change trans fluid & coolant when it needs to be, they'll last a long time. Also, Change the rear end lube every few years too if you run them as a daily driver. Dont forget to change the air filter when it begins to look dirty. Keep the front end & driveshaft Grease fittings greased up. If you have any doubts that the differentials leak, check on them periodically. Replace belts & pcv valve every 30k or so. I generally run a slightly heavier oil, such as 10w40 instead of 10w30 when the mileage gets up there or I add a 1/2 quart or so of Lucas