I have 3 vehicles with dex cool in them and they run just fine with zero issues. They are an 07 STS, 07 Sky, and my last is the oldest a 1965 Buick Wildcat with factory engine. The PO used dex cool after they pulled and flushed the block and and heater core along with having the radiator re-cored. And that old sled runs cool as a cucumber in 95+ degree heat in town or on the interstate.
So I've not had any issues with it, and all my other cars run Old School Green antifreeze, the 79 Scout, 85 Bonneville, and 95 F150.