Does the truck have a two piece driveshaft that has a splined connection? If so, the connection may need lube. I had a 02 F250 that had a clunk and that was the problem. The splined connection wasn't moving freely and would clunk when it unloaded. It required a specific synthetic grease that I got from the parts department at the local Ford dealer. Cheap easy fix. I hope this helps.
Funny you mention it, my friend has had that trouble with all his service trucks ( 5 ferds ). Either a clunk when transitioning over something and / or a constant vibration at certain highway speeds that he has chased for years. Done tires, driveshaft, ujoints and finally learned to live with it. His son started working as a diesel tech for Ferd last fall. His son had the work truck on the lift for rear brakes and mentioned it to the older tech in the shop. Old fella came out with a syringe and injected the magic poop in to the splines and said it was good to go. After living with the noise for at least 5 years its gone now and he's done it to the rest of the fleet. Its some special synthetic grease made from troll dung but it works
Yes the truck does have a splined two piece driveshaft. I have greased up the splines and reassembled, but I just used regular axle grease. I'll pick up a tube of that motorcraft grease and give it a shot! Thanks!