Mark,Jack, I agree with not ruining a back panel unless it was absolutely necessary. I am sure that the lock mechanism can be operated by a wire or cord from outside the door. It will mean opening the panel and eyeballing it all. If it can be routed down to the bottom, where it hangs out a tiny bit, that would be ideal. Or maybe tucked behind the bumper? Or even make an access hole BEHIND the license plate? Unscrew plate, pull wire, open door. I like that idea even more. I have only had one instance where the window would not stay locked. After a lot of grief I fixed it. But the OP's situation has me worried. This needs to be explored further.
It has me thinking more and more about it. I too would like to explore the possibilities. Unfortunately, I don't have a spare tailgate to experiment with.
Having an old one at my disposal. I'd be able to devise something I'm sure. Something like a pull cord/ cable, like you suggested, would do the trick.
I donated my spare tailgate to a friend that had a damaged tailgate. It went to a good home. He probably still has his old one. Perhaps I could pick his brain on a possible solution.
I like the idea of the cable situated behind the bumper and through the lower tailgate through a grommet. To be continued.