Lt1 Monte, How much thinner are you talking? I have several 350s of various years with both 2 and 4 bolt mains and would like to do some measuring in the area your talking about. Post those pics so I know exactly where your talking about to measure. Wouldnt that mean a crank for a 2 bolt and 4 bolt are different? The 2 bolt crank would have to be wider at the main journals to allow for the webbing. That would make the rod area smaller requiring thinner rods. I'm no machinist or pro builder but I have never heard of a machine shop measuring the webbing thickness. I have a 2 bolt vortec block so we can do some comparing with your 4 bolt vortec.
I believe 350 blocks were all cast the same or the casting number would have reflected it. I know gm wasnt exactly smart but I know they were cheap so extra casting to produce 4 bolt main makes no sense. And if they did they would have used a different casting number.