You mean by cutting and replacing metal?
Yes it likely would create new places for rust to start. Especially if you overlap the panels instead of doing it all nice and pretty and butt welding them.
And it gets borderline obsessive. BT,DT. My adopted rule of thumb is if I can't poke through it with a screwdriver, I'm not replacing it.
You'll never eradicate all of the rust, short of a rotisserie restoration. Even then, blasting doesn't clean the insides of panels or between pinch welds and seams. At some point you have to know when to call it good enough. Is it gonna rust again? Of course, eventually everything does. Will it be an issue in your lifetime or mine? Likely not.
I don't know exactly how you intend on using this truck, but unless you intend to park it in a museum with mirrors underneath of it, I wouldn't start cutting metal out.